Alveolar Soft-Part Sarcoma: A Case Report: Mexico Hospital,San Jose, Costa Rica | Alveolar soft-part sarcoma is a rare malignant entity with poor prognosis. Chemotherapy has limited activity in this type of sarcoma, we describe here the outcomes of the first case documented in our Institution with metastatic disease, treated exclusively with sunitinib. Soft-tissue sarcomas (STS) constitute an uncommon and heterogeneous group of tumors of mesenchymal origin, they share several clinical and pathological features and are usually considered as a group for diagnostic and therapeutic purposes, with the exception of specific particularities of some subtypes [1]. Alveolar soft‐part sarcoma (ASPS) is a rare, distinctive sarcoma, typically occurring in young patients. Although it displays a relatively indolent clinical course, the ultimate prognosis is poor and is often characterized by late metastases [2]. In advanced cases, with multiple metastatic involvement and recurrent cases, only palliative treatment is preferred due to its bad prognosis [3].We describe our experience treating a patients with ASPS with metastatic disease using tyrosine kinase inhibitor (sunitinib) with an outstanding survival and quality of life. For More Articles: Biomedical Journal Articles : https://biomedres.us/

Early Premolar Extraction: An Uncommon but Very Effective Treatment Option | The terminology “serial extraction” in Orthodontics was first described in the late 1920’s when Kjellgren [1] decided to plan the extraction of certain deciduous and permanent teeth at early stages of the dentition development. Since the extractions are under taken at the transitional dentition. This type of treatment is defined as “Early Treatment” in Orthodontics [2]. The main indication for this treatment approach is for patients with severe crowding caused by tooth size arch discrepancies [3,4]. In other words, when maxillary and/or mandibular arches cannot accommodate teeth, extraction becomes an interesting option. Although this treatment option has been used for almost a century in the contemporary orthodontics it’s indication is very specific. Since it’s an irreversible approach (permanent teeth are early extracted) the clinician should carefully diagnosis the case before selecting this option. In addition, as time passed by, orthodontics specialty has dramatically evolved and developed several options to gain space instead of extracting teeth. On the other hand, the idea to early extract permanent teeth continues to be an interesting treatment option in clinical orthodontics mainly in severely crowded patients. The aim of this paper is to present a case report of a ten-year-old male patient who presented severe crowding and treatment option was to extract four first premolars at early stages of the dentition development. For More Articles: Biomedical Open Access Journals : https://biomedres.us/

A Quantitative Assessment of an Alternative Anti-depression Therapy: Pilot Study | The goal of this pilot study was to evaluate psychometric testing to establish objective assessments for treating depression and co-morbid anxiety. Clients of The Sidman Institute were asked to take the BDI-II and BAI before and after three therapy sessions. Short-Term Sidman Hypnotherapy (STSH), independent of antidepressants, resulted in significant improvement by Wilcoxon analysis of BDI-II (Z=3.264, p=0.0011) and BAI (Z=3.233, p=0.0013) with large effect sizes (>0.9). Rumination-associated symptoms decreased significantly, and retrospective followup with previous clients indicated no relapse from one to three years post therapy, further indicating treatment effectiveness. For More Articles: Journal of Scientific and Technical Research : https://biomedres.us/

Treatment of Fingertip Gangrene in a Patient with Raynaud’s Phenomenon who Simultaneously Underwent Gastrectomy and Chemotherapy for Gastric Carcinoma: A Case Report | Raynaud’s phenomenon, characterized by recurrent vasospasm in the fingers and toes, is a common clinical disorder encountered by dermatologists. Hand-arm vibration syndrome is well known to cause secondary Raynaud’s phenomenon. The goal of treatment is to improve microcirculation and decrease inflammation, platelet activation, and vasospasm. We have reported a chronic case of Raynaud’s phenomenon in a 46-year-old aboriginal man with gastric carcinoma who simultaneously underwent gastrectomy and chemotherapy. The patient had developed gangrene at the tip of the right index finger and toes previously, and his fingers and toes had been amputated. The patient was hesitant to have another finger amputated. Hence, he was administered a combination therapy of pentoxifylline, extended-release nifedipine, and low molecular weight dextran for treating the acute symptoms of Raynaud’s phenomenon. At the later stages of his disease, only extendedrelease nifedipine was administered. Treatment with nifedipine resulted in an improvement in the symptoms. For More Articles: Biomedical Science Articles : https://biomedres.us/

Vitiligo Definition Classification Treatment and Prognosis A Personal Opinion | Vitiligo has no respect for race, socioeconomic status or age. The following are celebrities who have or have had Vitiligo. Michael Jackson, Lee Thomas Americo Garcia Holly Marie Combs, Winnie Harlow, Rasheed Wallace, Tamar Braxton Joe Rogan Sisqo Richard Hammond Thomas Lennon [1]. Vitiligo is a cutaneous pigmentary disorder caused by selective destruction or ‘temporary sickness’ of melanocytes presenting with complete or partial loss of skin color. Broader definitions are available from different authors and medical scientists [2]. I have defined the entity in the first instance in this way because it would explain many aspects and features of Vitiligo. A definition from the researcher referred to above [2] has the following key words: ‘Vitiligo, an autoimmune disorder characterized by localized and / or generalized depigmentation of the skin and / or mucous membranes’. For More Articles: Biomedical Research Articles : https://biomedres.us/

Uric Acid in Heart Failure: Controversy Factor in The Multiple Pathogenesis of The Disease | The majority of individuals with traditional cardiovascular risk factors contributing in heart failure (HF) risk exhibited increased serum levels of uric acid. The role of SUA in HF manifestation appears to be controversial. First controversy affects the fact that SUA plays an important role in inducing oxidative stress, inflammation, neuro humoral activation, and endothelial dysfunction. Being natural antioxidant uric acid contributes in prevention of cell damage and thereby may restore vascular function leading to reversion of endothelial dysfunction. Interestingly, there is a large body of evidence regarding that uric acid is able to regulate an activity of endogenous repair system through epigenetic mechanisms and activation of intracellular signaling, such as STAT3 and Akt. Indeed, uric acid mediates a survival of endothelial precursors, mediate their mobbing and differentiation, as well as coordinate a turn-over effect of metabolic memory phenomenon into repair capability of cell precursors. Probably, these controversies could have taken into consideration when clinical results of several studies are discussed. Although elevated SUA levels were found a strong predictor of adverse clinical outcomes in HF patients, there is assumption that final result of elevated uric acid may depend on cooperation between metabolic and epigenetic factors contributing in HF evolution. The short communication is depicted the importance of new clinical data to confirm the emerging reparative ability of SUA in HF and its role as promising target for treatment in cardiac failure. For More Articles: Biomedical Science Articles : https://biomedres.us/

Ecological and Cultural Values of Water Bodies: Recognising a Plural-Values Approach of Ecosystems | This article explores cultural and ecological values associated with water bodies, which can be considered helpful tools for both sustainable management and strengthening of responsibilities of the general public towards water bodies. The paper begins by setting out a bioindicator assessment for the quality of streams. That is then extended with cultural values of water quality. The article ends by discussing conclusions in relation to the importance of integrating socio-cultural perspectives into decision-making and water management. For More Articles: Biomedical Research Articles : https://biomedres.us/

Monitoring of Marketed Pork of Assam, Meghalaya and Manipur for Fenbendazole Residues | The study was undertaken to monitor marketed pork of Assam and its neighboring states Meghalaya and Manipur for Fenbendazole residues using Ultra High Performance Liquid Chromatography (UHPLC). 675 Samples of marketed pork of Assam, Meghalaya and Manipur were collected for the study. The samples after collection were preserved at -20 C. Recoveries of Fenbendazole in pork ranged from 89-98 %.Out of the tested samples, 29 samples were detected to be positive for trace residues of Fenbendazole which were well below the Maximum Residue Limit (MRL) value. For More Articles: Journal of Biomedical Research and Reviews : https://biomedres.us/

Multiple Myeloma Survival in A Rural Population | Disparities in cancer diagnosis, treatment and survival among different subgroups classified based on race, socioeconomic status and age have been previously noted. There is however a paucity of data addressing cancer disparities in rural populations. The purpose of this study is to examine multiple myeloma disease characteristics and survival in a rural population in comparison to their urban counterparts. This is a retrospective analysis of 81 multiple myeloma patients who presented to a New Mexico local hospital and cancer center from 2003 to 2013. Patients were classified to either rural or urban based on the Rural-Urban Commuting Area codes (RUCA) version 2.0, Categorization D. For More Articles: Biomedical Journal Articles : https://biomedres.us/

HIV Testing among Women in Namibia: Patterns and Determinants | HIV Testing and Counseling (HTC) remains an important entry to HIV Prevention, treatment, care and support services. HIV Testing Services (HTS) associated guidelines indicate that there are still significant gaps remaining in reaching undiagnosed HIV infected people and effectively linking them to treatment, care and support services with efficient use of limited available resources in Namibia. The objective of this study was to establish patterns and determinants of HIV testing, among women and to propose strategies to increase HIV testing among women. Secondary data from the Namibia Demographic and Health Survey (NDHS) was used to compute descriptive statistics and to fit a logistic regression to establish the determinants of HIV testing. Results indicated that younger women (p<0.001), except for those aged 15-19 years of age, those from Kavango (p=0.014), Kunene (p=0.013), Ohangwena (p=0.002), Omaheke (p<0.001) and Oshana (p=0.007) regions and those who reside in urban areas (p=0.001) were more likely to go for an HIV testing. Women with lower educational attainment (p<0.001) were less likely to go for HIV testing. HIV testing was also influenced by the number of sexual partners, culture, socio-economic status, and marital status. Intervention programs to increase the uptake of HIV testing should also target older women, rural areas and those with lower educational attainment. For More Articles: Biomedical Open Access Journals : https://biomedres.us/