Is c-kit Gene Product involved in Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma? A Pilot Study Oriented Towards Patient Outcome | Over 90% of head and neck cancers are squamous cell carcinomas (SCC) which are the most common malignancies in the oral cavity. In spite of improved therapeutic procedures, SCCs generally exhibit poor prognosis and in addition, treatment results in significant functional and cosmetic defects. Several factors contribute to a poor prognosis for upper aerodigestive tract SCC patients including the delayed detection of cancerous lesions and the tendency to develop multifocal malignancy and premalignant lesions as a consequence of field cancerization. It has been generally accepted that prompt detection of early oral cancer or epithelial dysplasia is required to improve prognosis. Therefore it is important to identify markers for carcinoma progression. For More Articles: Biomedical Journal Impact Factor : https://biomedres.us/

Laparoscopic Removal of Intra Abdominal MigratedIntrauterine Device Involved in the Omentum | The presence of an intrauterine device migrated into the abdominal cavity can be detected incidentally or due to complications (the most frequent abdominal pain, obstructive 8complications or cause of acute abdomen). We report the case of a woman of 35 years, with an intrauterin device (Mirena®) misslocated in the abdominal cavity incidentally 18 months after puerperium (6 months after implantation). After the detection by abdominal conventional X-ray and transvaginal sonography, the management was a laparoscopic surgery in order to remove the device. It was firmly adhered to the major omentum in the right low quadrant. The surgery was performed with no problems and the discharged of the patient was at 12 hours uneventful. The follow up at first month was correct in vaginal and abdominal exploration. For More Articles: Journal of Scientific and Technical Research : https://biomedres.us/

Pinning Down HELLP: A Review | Preeclampsia and HELLP syndrome, both disorders unique to pregnancy, remain a major cause of maternal and neonatal mortality and morbidity worldwide. It is the most common medical disorder complicating pregnancy. In both of these disorders, the liver is a major target with often devastating consequences. The pathogenesis of hepatic damage in cases of severe preeclampsia and HELLP syndrome is not well understood. Diagnosis of HELLP syndrome is heavily relied upon laboratory investigation. In the management, first priority is to assess and stabilize the maternal condition, particularly coagulation abnormalities followed by evaluation of fetal well‑being and finally, a decision must be made as to whether or not immediate delivery is indicated. Women with a prior history of HELLP syndrome carry an increased risk of at least 20% (range 16%-52%) risk of recurrence of some form of hypertension, so future pregnancy counseling and follow up is essential. For More Articles: Biomedical Science Articles : https://biomedres.us/

A Review of the Relationship between Obesity and Periodontal Diseases | Obesity and periodontal diseases (PD) are very prevalent among U.S. adults during recent years [1-4]. Since both can lead to severe chronic health conditions and impair people’s life quality by exerting similar influences [5-10], a clear understanding of the association between obesity and periodontal diseases is warranted to reduce health and medical costs in the U.S. [5] The objective of this review is to explore the influence of obesity/overweight on development and treatment outcome of PD, and to explore possible mechanisms of interaction between obesity and PD. PubMed and Go Pubmed were used to search for related preclinical, observational, clinical studies and meta-analyses that investigated the relationship between obesity and PD. They were reviewed to determine the association and to summarize mechanisms of interaction between the conditions. Combinations of “obesity” or”overweight” or “fat-induced obesity” or “weight changes” AND“gingivitis” or “periodontitis” or “periodontal diseases” were used as key terms. Studies conducted in the past six years. For More Articles: Biomedical Research Articles : https://biomedres.us/

A New Branch of Medicine | In the beginning there were two branches of medicine and only two were needed. We crawled from our caves early to forage all day for food. Fire was useful even though it burned down some dens before we were ready to leave for a cleaner, less ravaged new site. We discovered what plants were good to eat and which were poisonous. Some were used to heal and they became today’s pharmaceutical industry. We found ways to cut plants, animals and enemies and this became surgery. It was a strenuous life. There was no thought of exercise. Mere existence was physically exhausting which was fine because we had evolved to be on the go all day. Back in the cave we were with people we had grown up with. There were no secrets. We supported each other. Those who were lucky enough to not be caught by a tiger or the tribe over the hill lived to an old age, maybe sixty winters and they died in their sleep. For More Articles: Biomedical Open Access Journals : https://biomedres.us/

The Underrated Carbonate Radical (CO3•–) – Detoxification and Reduced Formation by Melatonin | Carbonate radicals are frequently overlooked or underrated oxidants that have a considerably larger range of action than the short-lived hydroxyl radicals. They possess sufficient reactivity for abstracting electrons or hydrogen atoms from many biomolecules. Carbonate radicals are formed in several reactions, e.g., via hydrogen abstraction from bicarbonate by a hydroxyl radical, through interaction of a formate radical with bicarbonate and, most importantly, from the peroxynitrite-carbon dioxide adduct. All these pathways of formation indicate an important role of carbon dioxide and bicarbonate levels for the generation of carbonate radicals and, therefore, many oxidizing reactions with aromates can be considerably enhanced by adding bicarbonate. Under physiological and, even more, pathophysiological conditions, high CO2/HCO3– concentrations are found in mitochondria and in situations of under-perfusion or ischemia. Increased levels of nitric oxide considerably increase via generation of peroxynitrite the formation of carbonate radicals, effects of relevance with regard to inflammation, Alzheimer’s disease, stroke, and all pathologies related to mitochondrial dysfunction. Melatonin counteracts both the formation and persistence of carbonate radicals, by down regulating inducible and neuronal NO synthases, by scavenging carbonate radicals, and by protecting mitochondria. For More Articles: Journal of Scientific and Technical Research : https://biomedres.us/

Confocal Raman Spectroscopic Analysis of the Changes in Type I Collagen Resulting from Amide I Glycation | The process of glycation is a non – enzymatic reaction between sugar and free amino group of proteins, leading to skin aging. In this sense, the present study aimed to analyze the changes resulting from glycation in the dermis by Confocal Raman spectroscopy. The analysis was performed with 30 patients with skin types I and II, divided into 3 groups: 10 healthy young women aged 20-33 years, 10 healthy elderly women and 10 elderly women with diabetes type I and II in the age group of 65-80 years. Raman spectra were collected from 70-130 microns in depth and the data were analyzed. It was observed that the amide I band was centered at 1664 cm-1 for the young participants and healthy elderly which may be due to the presence of water and change in the direction of the shorter wavelength was observed which is centered around 1662 cm-1. Considerable changes were observed for the elderly participants with diabetes and the peak was centered around 1658 cm-1. Thus, it is inferred that hyperglycemia in elderly subjects with diabetes mellitus accelerate the formation of advanced glycation end products, which increase the type I collagen degradation in human skin. For More Articles: Biomedical Science Articles : https://biomedres.us/

A Case of Immediate Loading with a Fixed Detachable Prosthesis and a Removable Definitive Solution via a Denture with Telescopic Attachments | Immediate Loading is mostly appreciated by patients, since they do not have to stay edentulous until the osseointegration. For this purpose there must be an implant system providing abutments suitable for screw retention and a prefabricated restoration. In this case report the procedures for this treatment modality are described in a detailed way. Additionally, the return from fixed to removable upon request of the patient due to easier cleaning was explained, too. The lab procedures and the makeover to a telescopic denture was looked into in this case report. For More Articles: Biomedical Research Articles : https://biomedres.us/

Humans and Dogs with Cancer and their Foods | One in three people gets cancer. One in four dogs got cancer. In western countries where dogs are treated very well, dogs are fed processed foods mostly. These processed foods are the prime suspects for one of the causes for cancer in dogs. In particular, it is the red meats used and the preservatives contained in the dog foods which are probably the sources of carcinogenicity. Healthy dog foods include all foods healthy for human beings with many exceptions, like bone-in fish, chocolates, coffee, avocados. There is a long list of human foods which cannot be fed to dogs. Veterinary physicians should regularly check the mouths of dog, for early detection of mouth cancer. Like for humans, early detection of cancer leads to better recovery from the disease with proper therapy. For More Articles: Journal of Biomedical Research and Reviews : https://biomedres.us/

Tele-Care (TC) For Comparative Individual Patient Effectiveness Research (CIPER) In Dentistry | In the context of translational healthcare, the construct of Evidence-Based Dentistry (EBD) consists of two fundamental and intertwined domains. From the viewpoint of research, EBD is driven by the paradigm of comparative effectiveness research, which seeks to uncover the consensus of the best available evidence. From the perspective of dental practice, EBD strives to provide patient-centered, effectiveness-focused and evidence-based treatment intervention. Patient-centered care implies that the best evidence base that serves as the basis of effectivenessfocused intervention must be derived from a process of comparative individual patient effectiveness research (CIPER). Patient-centered care also implies that novel tele-health communication technologies (Tele-Care, TC) must be developed and standardized across dental specialties to distribute the best evidence base to clinicians, patients, caregivers and other stakeholders in real-time. In brief, the next decade will witness significant progress in perfecting EBD by improving TC modalities of distribution of the consensus of the best evidence base obtained through stringent CIPER protocols. For More Articles: Scientific Research Articles on Biomedical : https://biomedres.us/