Advances in the Treatment of FLT3-Mutated AML | AML is a heterogeneous disease and is the most common acute leukemia in adults. It has an annual US incidence over 20,000 and death rate of over 10,000 per year. The 5-year remission rates after conventional induction therapy is 40% below 60 years and 10%-20% in older patients. FLT3-ITD mutation has been added to the WHO risk stratification as a predictor of poor prognosis. On April 28, 2017 FDA approved midostaurinin combination with standard cytarabine and daunorubicin induction and cytarabine consolidation for treating adult newly diagnosed AML patients who are FLT3 mutation positive as detected by an FDA approved test. For More Articles: Scientific Research Articles on Biomedical : https://biomedres.us/

Astaxanthin Pattern in Mangroves: A Case of Species- Specificity | Astaxanthin, a naturally occurring carotenoid pigment possessing strong antioxidant property has been detected to play a vital role in the protection against lipid peroxidation and oxidative damage of LDL cholesterol, cell membrane, cells and tissues. It is available from several biological sources particularly the microalgal species Haematococcus pluvialis, but the salt tolerant mangrove vegetation present in the deltaic lobe of Indian Sundarbans has been documented as one of the most potential sources of astaxanthin. This paper documents the accumulation of astaxanthin in six species of mangroves (Avicennia officinalis, Avicennia alba, Avicennia marina, Sonneratia apetala, Aegiceros corniculatum and Bruguiera gymnorrhiza) at ten different stations having different environmental conditions in the Hooghly-Matla estuarine complex of Indian Sundarbans. Although these six species share the same brackish water media, but significant variation in the leaf astaxanthin level confirms the concept of species-specificity and effects of various physico-chemical variables on mangrove astaxanthin. For More Articles: Biomedical Journal Articles : https://biomedres.us/

A New Perspective of Agroecosystem in 21st Century | Land is a living legend, including all eroded and forest land that all would contribute to agriculture. In a wider perspective, a long-term view will have to be taken to manage our soil, plant and bio-resources. Sustainable intensification of agriculture productivity enhancement and loss prevention is the only option to meet our growing requirement. Integrated water resource management approach for irrigated cropping systems per unit of agriculture water use holds key to both food and environmental security. For harnessing effective ecosystem based production, enhanced water use efficiency, promoting balanced use of nutrients and water and soil biota test based technology adoption is the needs of hour. For More Articles: Biomedical Open Access Journals : https://biomedres.us/

Donate Blood… Gift Life | Every year our nation needs 5 crore units of blood where as we get half the quantity of blood. So 50% of people do not get the blood or their products in emergencies. There cannot be a substitute of blood. Every 2 seconds somebody needs blood or their products. To fulfill the need we need 38000 blood donors every day. One unit of blood can save 3 lives. Wow what a gift we can give it to society. The average red blood transfusion need per day is 3 pints a day. Patient with sickle cell anemia, Thalessemia Major, Severe anemia, a plastic anemia, acute blood loss due to diseases or accidents, Thrombocytopenia due to bone marrow suppression, cancer patients needs transfusion. Blood and blood products cannot be manufactured in any industries or by any technological or biological aid. It is to be donated by a human being to other human being. For More Articles: Biomedical Research Articles : https://biomedres.us/

The Effect of Chronic Trimetazidine Administration on Left Ventricular Function and Quality Of Life in Libyan Patients with Heart Failure| Heart failure is a major cardiovascular disease and public health problem. It is complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of the blood. Trimetazidine is a cardio-protective drug that exerts cytoprotective effects by inhibition of the mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. For More Articles: Biomedical Science Articles : https://biomedres.us/

Top Counter Terrorism Expert Says UK Counter Terrorism Strategy was Based on Luck All the Time | The United Kingdom has arguably the top counter-terrorism practitioners in the world. The U.S. Army Special Forces’ Delta Force was modeled from the British Special Air Services, MI-6 is the top partner to the US Intelligence Community and MI5’s camera surveillance platform is the most comprehensive imagery collection platform in any city in the world. The Metropolitan Police are well trained, with a long history of deep penetration in the community. There is little question that the UK has world-class counter terrorism capacity and capability, both theoretical and operational, but recent attacks indicate that their anti-terrorism strategy needs reform. For More Articles: Journal of Scientific and Technical Research : https://biomedres.us/

Update on Mesh used for Pelvic Organ Prolapse | The inevitable outcome of this has been the concern women have of the safety of mesh used for prolapse surgery and the unfortunate consequence of questioning the benefits of the highly effective midurethral sling products used for the treatment of stress urinary incontinence. We were of the view that at this point of time it would be useful to bring you up to date on the current state of mesh products used of pelvic surgery. Fore More Articles: Biomedical Science Articles : https://biomedres.us/

Some Spiritual, Social, Cultural and Hystorical Aspects of Alcoholism Prevention in North-Easter Bosnia | Although the harmful effects of alcohol have long been observed, organized social measures for the prevention of excessive consumption of alcoholic beverages were taken relatively late. In the beginning they were purely repressive measures through both religious and secular laws of through moral lessons and educational recommendations. There are not many experts who have publicly advertised against this scourge of the family, society and every individual who became a victim of alcoholism. Teetotaler societies in Bosnia-Herzegovina began with the establishment and work at the late 19th and early twentieth century. The authors provide a historical overview of societal and professional institutions that fight against alcoholism in the area of northeast Bosnia following the definition of the World Health Organization, that alcoholism is illness and alcoholic is a patient. Through the period before World War II, between the two world wars, the national liberation struggle period from 1941 to 1945, and the post-war socialist enthusiasm to the last war from 1992 to 1995. For More Articles: Biomedical Research Articles : https://biomedres.us/

Examining Contrasting Views from Behaviorism and Psycho- Biological PerspectivesPerspectives of The Pharmacological Modulation of Ca2+/ Camp Signaling Interaction as a New Neuroprotector Therapeutic Strategy for Amyotrophic Lateral Sclerosis (ALS) | Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease characterised by progressive muscular paralysis reflecting selective degeneration and death of motor neurons in the primary motor cortex, brainstem and spinal cord. Several evidences suggest the involvement of the imbalance of the intracellular Ca²⁺ homeostasis in the death of motor neurons in ALS. It is now recognized that the interaction between intracellular signaling pathways mediated by Ca²⁺ and cAMP (Ca²⁺/cAMP signalling interaction) plays as a key role in several cellular processes of mammalians, including neurotransmission and neuroprotection. For More Articles: Journal of Scientific and Technical Research :https://biomedres.us/

Examining Contrasting Views from Behaviorism and Psycho- Biological Perspectives | First and foremost, humanistic psychology originated during the 1960’s which sought out to examine the components of selfidentity, self-growth, and self-worth after the post-war American society [1]. Humanistic psychology espoused the belief that mental illness psychologists examined the patient in a holistic manner along with the philosophy of the “growth-driven self” [1] The history of psychology has shown students that another version of helping mental illness in comparison to previous theories of psychoanalysis (Freud) and behaviorism (Tolman) did exist. In looking at the evolution of the field of psychology, as people and the environment have evolved, so has the psychology field in keeping up with human development. According to [2] humanistic psychology began as a revolt against former methods of psychological theories. The goal of humanistic psychology focused upon characteristics proposing a “free will” eliciting purpose, in search for meaning in life, and achievement of self-actualization [2]. An important focus of humanistic psychology has been “self-actualization”; however, from a clinician’s point of view another part in self-development and self-achievement is “free will”. The power of choice to make good decisions or poor ones concerning personal development determines who we are and who we will become in the future. For More Articles: Journal of Biomedical Research and Reviews : https://biomedres.us/