Yoga in Mental Health | Yogic techniques, such as asana and pranayama of Hatha Yoga, and various meditations, have been trailed through clinical and other scientific procedures. The results have established the preventative and therapeutic applications of the yogic practices. The explanation of the underlying physiological and chemical basis of these practices has given them wide appeal and acceptability throughout the world. We have witnessed their success in curing some supposedly incurable common diseases like asthma, diabetes, hypertension, etc., without causing adverse side-effects. However, the world of science is yet to appreciate fully that Yoga is basically a science of the mind. For More Articles: Biomedical Journal Articles : https://biomedres.us/

Breakthrough Treatment for Mantle Cell Lymphoma | MCL has a dismal prognosis (“the worst lymphoma to have”), with a median OS rate of 3 years only. Prognosis of limited stage disease is almost similar to that of stage lll MCL No curative therapy has been established so far. The US FDA granted breakthrough therapy designations to a bruton tyrosine kinase inhibitor, acalabrutinib in MCL patients who have previously received at least one line of therapy. Furthermore, the combination of bortezomib and a retinoid compound, fenretinide is synergistically cytotoxic against MCL lines and warrants further evaluation in vivo and in clinical trials. In addition, the combination of anti-Mcl-1 lipidoid nanoparticles with other forms of targeted therapy offers hope for reducing or replacing cytotoxic chemotherapy as standard treatment for MCL that over express Mcl-1. For More Articles: Biomedical Open Access Journals : https://biomedres.us/

Agriculturally Important Micro biomes: Biodiversity and Multifarious PGP Attributes for Amelioration of Diverse Abiotic Stresses in Crops for Sustainable Agriculture | The micro biomes from plant and different extreme environments have been reported and characterized for genotypic and multifarious functional attributes. The plant micro biomes (phyllospheric, endophytic and rhizospheric) and micro biomes of extreme habitat (acidophilic, alkaliphilic, halophilic, psychrophilic, thermophilic and xerophilic) are natural bioresearches, which may play critical roles in the maintenance of global nutrient balance and ecosystem functions. The crops microbiomes and extreme habitat microbiomes with plant growth promoting (PGP) attributes have emerged as an important and promising tool to enhance plant growth, crop yield and soil fertility. The microbes possesses PGP attributes such as solubilization of phosphorus, potassium and zinc; ACC deaminase; biological nitrogen fixation and production of auxin, gibberellic acids, cytokinin, Fe-chelating compounds, ammonia, HCN, hydrolytic enzymes and secondary metabolites. These PGP microbes could be applied as biofertilizers [An ecofriendly agriculturally important bioinoculants] to replace the chemicals fertilizes and for amelioration of different abiotic stresses in crops inclining, salinity, temperature, drought and pH. The agriculturally important microbes may play important role in plant growth, development, and soil health for sustainable agriculture. For More Articles: Journal of Scientific and Technical Research : https://biomedres.us/

Osteonecrosis of the Jaws: The Awareness of the Patient at Risk | Individuals under anti-angiogenic or antiresorptive bone medications are in risk to develop medication related osteonecrosis of the jaws (MRONJ). The most common trigger event that can lead to MRONJ is bone manipulation, such as dental extraction. Thus, a proposed consent form to be use by clinicians attending individuals at risk of development of MRONJ is proposed. Three clinicians with experience in dental treatment of individuals exposed to anti-angiogenic or antiresorptive-reabsortive bone medications developed a consent form based on technical and scientific content. A clear and simple text was elaborated for patient’s knowledge and consent registration. Clinicians should always inform patients about the condition and the risks of the procedures during dental treatment, and those individuals in risk to develop MRONJ should sign a consent form, before invasive procedures are performed. For More Articles: Biomedical Science Articles : https://biomedres.us/

Alterations in Cellular Cholesterol Content Can Be a Potential Anticancer Strategy | Cholesterol, a unique lipid molecule biosynthesized by all animal cells, is an essential structural constituent in cell membranes to maintain their structural integrity and fluidity. Cholesterol is critical to synthesis of hormones, vitamin D and bile acid, multiple cellular signaling, intracellular transport and a variety of cell functions [1,2]. Cholesterol is necessary to the structure and function of caveolae and clathrin-coated pits, enabling the endocytotic activity [3,4]. In recent decades, increasing lines of evidence show that lipid rafts, which are membrane micro domains assemble glycosphingolipids, protein receptors and kinases, preferentially associate with cholesterol and saturated lipids in driving a wide variety of cellular signaling pathways [5,6]. Not only in normal cellular and physiological functions, intracellular cholesterol homoeostasis once deregulated can be responsible for the development of malignancies through decreasing chemotherapeutic susceptibility and increasing resistance in cancer cells, inhibiting the release of mitochondrial cell death-promoting molecules, activating survival kinases and many other mechanisms [7-9]. Epidemiological studies also have suggested a positive correlation between serum cholesterol levels and cancer risk [9-11]. These studies support the notion that the development of cholesterol-lowering agents can be a potential anticancer strategy. For More Articles: Biomedical Research Articles : https://biomedres.us/

Focus on the Melatonin Metabolite N 1-Acetyl-5-methoxykynuramine (AMK) | The melatonin metabolite N¹-acetyl-5-methoxykynuramine (AMK) is a bioactive compound that acts as a potent inhibitor of cyclooxygenases, of neuronal NO synthase and myeloperoxidase, as a downregulator of cycloxygenase-2 and inducible NO synthase. Additionally, AMK is a potent scavenger of hydroxyl, peroxyl and carbonate radicals. It eliminates singlet oxygen more efficiently than histidine and related compounds. As a scavenger of all NO redox congeners, it forms a stable compound, 3-acetamidomethyl-6-methoxycinnolinone, that does not re-donate NO. Carbamoylating metabolites convert AMK into N-[2-(6-methoxyquinazolin-4-yl)-ethyl]-acetamide, another stable product. Upon oxidation, AMK forms an adduct-generating intermediate, which can attach to aromates, among them tyrosine and tryptophan. Protein AMKylation at tyrosines may cause inhibition of enzymes. With regard to receptor tyrosine kinases, this possibility may explain the observed growth inhibition in keratinocytes. For More Articles: Journal of Biomedical Research and Review : https://biomedres.us/

A Spiritual, Soul, Body Model as the Non-Biomedical Model | The value has transformed into focused on the materials and family destruction globally during the time of making extra efforts on the economics, the ten leading deaths of Taiwan includes cancer, depression mad suicide which has identified the unhealthy body, mind and spirituality. How could we alter, repair, and heal own spirituality to lessen the sinful minds, psychology, and emotion approaching the balanced status for further improving the healthy bodies? It is really a worthwhile discussion and research topic. Hawkey [1] proposed a question as the interaction between the spirituality and soul of human beings, which means that the hurt spirituality could induce the sinful mind that might impact the psychology and emotion of human beings that she has called as soul. The hurt spirituality included spirituality of timid, imprisoned, tarnished, crush, sad, orphan, faint, and sinful minds included the un-forgiveness, resentment, angry, revenge, greedy, self-blame, jealous, bitterness, and the consequences would induce the anxiety, stress, fear, shame, and sorrow. Following the Hawkey [1] theory, Ku [2] proposed the hypothesis of spirituality, soul, and body model that not only the hurt spirituality could induce the sinful mind that might impact the psychology and emotion of human beings, gradually it also impact the bodies of human beings, resulting in the toxin blood with reducing the immune system which caused the phenomena of sickness of human beings [3-8]. Instead of the traditional model of body, mind, spirituality, the mainstream of spirituality, soul, and body model is to hypothesize the spirituality with the function of the scientific influences for the souls and bodies of human beings. Following (Figure 1) is the spirituality, soul, and body model. For More Articles: Scientific Research Articles on Biomedical : https://biomedres.us/

Assessment of Cognitive Impairment in Older Research Participants | In any clinical trial or observational study, a certain level of cognitive function is required in order to ensure participant safety and ability to comply with the study protocol. Participants should adequately understand what is involved in their participation, as well as any potential risks or benefits of participation. The costs of using a specific screening method, however, need to be weighed against the information obtained. This prevents the inefficient use of available resources, such as avoiding assessments that require an extremely long administration time and unnecessarily increase participant burden. Due to the inherent challenges in obtaining a valid assessment of cognitive function in a time efficient manner, all potential assessment measures should be evaluated with a “best fit” approach. Keeping this “best fit” approach in mind, we reviewed and evaluated a number of screening tests for assessing cognitive impairment based on recommendations provided by experts in the field. Based on our review, we provide recommendations about existing methods for screening cognitive function in older research participants. Using the “best fit” approach, we would recommend the Mini-Mental State Examination (MMSE) to screen for cognitive impairment in older research participants. Other measures, such as the Cognitive Abilities Screening Instrument (CASI) and Modified Mini-Mental State (3MS), are indeed promising, but the MMSE can be administered in a time efficient manner and has the highest amount of supporting literature. For More Articles: Biomedical Journal Impact Factor : https://biomedres.us/

Partial Segmental Testicular Infarction in a Mature Rhesus Macaque (Macaca mulatta) Resembling a Human Condition | This paper describes a case of segmental testicular infarction (STI), a rarely described human condition resulting from partial ischemia of the testis and often resulting from complex, organic, traumatic or metabolic causes, although an idiopathic etiology has been also considered. Being an important human occurrence, STI has not been reported in non-human primates (NHP) and this work is aimed to characterize a fortuitous case of STI in a 20-year-old male rhesus macaque, demonstrated by clinical findings, ultrasonography and histopathology studies. Clinically, the subject presented a significant scrotal wall thickening and in duration of the right testis palpated at its lower pole, while ultrasonography revealed a hypoechoic irregular mass of poorly defined margins. Upon excising this organ, the histological findings demonstrated a well-defined hemorrhagic nodule measuring 1 cm in diameter consistent with segmental testicular infarction, confirmed by further detailed observations disclosing arteriolar wall thickening and a double lumen, indicating post-infarctrecanalization considered an analogous condition seen in human stroke. For More Articles: Biomedical Journal Articles : https://biomedres.us/

An Explication on Broadening the Definition and Scope of Maximum Available Resources under the General Comment 14 of the ICESCR to include Islamic Taxation in Financing the Right to Health | There exists no comprehensive definition on what constitutes “available resources” as envisaged under article 2.1 of the International Covenant on Economic, Social and Cultural Rights. There is also an absence of an extensive discourse on this definition beyond stating that it refers to both the resources existing within a state as well as those available from the international community through international cooperation and assistance. The definition does not recognize Islamic forms of taxation that are domestically available to an Islamic as well as a secular state. Accordingly, the problem identified in this explication is that of linking zakat; a form of Islamic taxation, to the concept and definition of maximum available resources. The book by Waris (2015) argues that there is a link between taxation and human rights (the right to health being among such rights). Waris pushes this proposition to the point of demonstrating the validity of the argument that rights require resources for their realization and subsequent enforcement, but she stops short of discussing the exact fiscal mechanism that could be used for the realisation and enforcement of specific rights. This explication having identified this gap aims to advance an argument that allows for broadening the international community understands of what constitutes maximum available resources that a state can utilise to finance the right to health. It proposes the introduction of zakat as a potential method of mobilising financial resources domestically available and argues for its inclusion in the definition and scope of maximum available resources. For More Articles: Biomedical Open Access Journals : https://biomedres.us/