Bi-Directional Interaction between Systemic Botrytis Cinerea, and Aphid Myzus Persicae on Lettuce Plant | Bi-directional interaction between economically important fungal pathogen Botrytis cinerea and aphid Myzus persicea causes serious economic losses to the crop plants resulting in loss of both time and money spend. In bi-direction interaction the fungal pathogen and insect herbivores, can both interact directly with the plant and interact indirectly with each other as they struggle to compete for the resources of the plant. We investigated the bi-directional interaction between the necrotrophic and economically important fungal pathogen Botrytis cinerea Pers Fr (Helotiales Sclerotiniaceae) and the aphid Myzus persicae (Hemiptera Aphididae) on plant host, lettuce Lactuca sativa (Asteraceae: Compositae). Botrytis cinerea on host plant causes a brownish discoloration of the leaf petiole accompanied by the rotting of the leaves, however, presence of aphids on lettuce plants causes’ economic damage directly through injury and indirectly through virus transmission, resulting in wilting and head contamination. For More Articles: Biomedical Research Articles : https://biomedres.us/

Nasopalatine Cyst: A Silent Growing Lesion | The nasopalatine cyst (NPC) is a non-odontogenic cyst, it occurs mainly in adult patients in some cases can bring difficulties to the diagnostic due to its silent growing. We are going to present in this paper report case in a 10-year child emphasizing the histophatological characteristics and the findings in obtained images by Cone Beam Computed Tomography (CBCT). The nasopalatine cyst (NPC) represents from 38 to 43.66% of the non-odontogenic cysts, followed by oral lympho epithelial cyst and epidermoid cyst. This cyst wound still represents about 1.87 to 10% of the jaw cysts. With major frequency in men, between the fourth and sixth decades [1-3].This non-odontogenic cyst is labeled as a development cyst, and its pathogenesis are not clear described yet, are believed to arise from the remnants of nasopalatine ducts in the incisive canal [4]. For More Articles: Journal of Biomedical Research and Review : https://biomedres.us/

Spontaneous Kidney Bleed after Acute Coronary Syndrome Treatment | Spontaneous kidney bleed is a rare condition. Renal tumors are the most common cause of bleeding whereas anticoagulant and antiplatelet therapy are some of the less common causes. We present a case of a 72 year old male patient with acute coronary syndrome (ACS), who developed massive painless hematuria after ACS treatment. He was found to have spontaneous right pelvical iceal bleed by computed tomography (CT). The patient was successfully treated conservatively. Spontaneous kidney bleed is a diagnostic dilemma. It is a rare condition in clinical practice. Although lots of research has been done in this subject, still it remains elusive. The most common cause of bleeding are benign and malignant renal tumors, especially angiomyolipomas and renal cell carcinoma. For More Articles: Scientific Research Articles on Biomedical : https://biomedres.us/

CRISPR Technology Challenge Facing the Numerical Integrity of Whole Human Genome DNA | Global analysis of 3 human genomes of increasing levels of evolution (Neanderthal /Sapiens Build34 / Sapiens hg38) reveals 2 levels of numerical constraints controlling, structuring and optimizing these genome’s DNA sequences. A global constraint – called “HGO” for “Human Genome Optimum” – optimizes the genome at its global scale. The same operator applied to each of the 24 individual chromosomes reveals a hierarchical structure of these 24 chromosomes. Then analysing the single strand DNA CG / TA proportions at whole chromosomes and genome scale reveals strong fine-tuned numerical ratios evidencing the “closure” nature (Varela’s autopoiesis theory) of whole human genome. For More Articles: Biomedical Journal Impact Factor : https://biomedres.us/

Yoga in Mental Health | Yogic techniques, such as asana and pranayama of Hatha Yoga, and various meditations, have been trailed through clinical and other scientific procedures. The results have established the preventative and therapeutic applications of the yogic practices. The explanation of the underlying physiological and chemical basis of these practices has given them wide appeal and acceptability throughout the world. We have witnessed their success in curing some supposedly incurable common diseases like asthma, diabetes, hypertension, etc., without causing adverse side-effects. However, the world of science is yet to appreciate fully that Yoga is basically a science of the mind. For More Articles: Biomedical Journal Articles : https://biomedres.us/

Breakthrough Treatment for Mantle Cell Lymphoma | MCL has a dismal prognosis (“the worst lymphoma to have”), with a median OS rate of 3 years only. Prognosis of limited stage disease is almost similar to that of stage lll MCL No curative therapy has been established so far. The US FDA granted breakthrough therapy designations to a bruton tyrosine kinase inhibitor, acalabrutinib in MCL patients who have previously received at least one line of therapy. Furthermore, the combination of bortezomib and a retinoid compound, fenretinide is synergistically cytotoxic against MCL lines and warrants further evaluation in vivo and in clinical trials. In addition, the combination of anti-Mcl-1 lipidoid nanoparticles with other forms of targeted therapy offers hope for reducing or replacing cytotoxic chemotherapy as standard treatment for MCL that over express Mcl-1. For More Articles: Biomedical Open Access Journals : https://biomedres.us/

Agriculturally Important Micro biomes: Biodiversity and Multifarious PGP Attributes for Amelioration of Diverse Abiotic Stresses in Crops for Sustainable Agriculture | The micro biomes from plant and different extreme environments have been reported and characterized for genotypic and multifarious functional attributes. The plant micro biomes (phyllospheric, endophytic and rhizospheric) and micro biomes of extreme habitat (acidophilic, alkaliphilic, halophilic, psychrophilic, thermophilic and xerophilic) are natural bioresearches, which may play critical roles in the maintenance of global nutrient balance and ecosystem functions. The crops microbiomes and extreme habitat microbiomes with plant growth promoting (PGP) attributes have emerged as an important and promising tool to enhance plant growth, crop yield and soil fertility. The microbes possesses PGP attributes such as solubilization of phosphorus, potassium and zinc; ACC deaminase; biological nitrogen fixation and production of auxin, gibberellic acids, cytokinin, Fe-chelating compounds, ammonia, HCN, hydrolytic enzymes and secondary metabolites. These PGP microbes could be applied as biofertilizers [An ecofriendly agriculturally important bioinoculants] to replace the chemicals fertilizes and for amelioration of different abiotic stresses in crops inclining, salinity, temperature, drought and pH. The agriculturally important microbes may play important role in plant growth, development, and soil health for sustainable agriculture. For More Articles: Journal of Scientific and Technical Research : https://biomedres.us/

Osteonecrosis of the Jaws: The Awareness of the Patient at Risk | Individuals under anti-angiogenic or antiresorptive bone medications are in risk to develop medication related osteonecrosis of the jaws (MRONJ). The most common trigger event that can lead to MRONJ is bone manipulation, such as dental extraction. Thus, a proposed consent form to be use by clinicians attending individuals at risk of development of MRONJ is proposed. Three clinicians with experience in dental treatment of individuals exposed to anti-angiogenic or antiresorptive-reabsortive bone medications developed a consent form based on technical and scientific content. A clear and simple text was elaborated for patient’s knowledge and consent registration. Clinicians should always inform patients about the condition and the risks of the procedures during dental treatment, and those individuals in risk to develop MRONJ should sign a consent form, before invasive procedures are performed. For More Articles: Biomedical Science Articles : https://biomedres.us/

Alterations in Cellular Cholesterol Content Can Be a Potential Anticancer Strategy | Cholesterol, a unique lipid molecule biosynthesized by all animal cells, is an essential structural constituent in cell membranes to maintain their structural integrity and fluidity. Cholesterol is critical to synthesis of hormones, vitamin D and bile acid, multiple cellular signaling, intracellular transport and a variety of cell functions [1,2]. Cholesterol is necessary to the structure and function of caveolae and clathrin-coated pits, enabling the endocytotic activity [3,4]. In recent decades, increasing lines of evidence show that lipid rafts, which are membrane micro domains assemble glycosphingolipids, protein receptors and kinases, preferentially associate with cholesterol and saturated lipids in driving a wide variety of cellular signaling pathways [5,6]. Not only in normal cellular and physiological functions, intracellular cholesterol homoeostasis once deregulated can be responsible for the development of malignancies through decreasing chemotherapeutic susceptibility and increasing resistance in cancer cells, inhibiting the release of mitochondrial cell death-promoting molecules, activating survival kinases and many other mechanisms [7-9]. Epidemiological studies also have suggested a positive correlation between serum cholesterol levels and cancer risk [9-11]. These studies support the notion that the development of cholesterol-lowering agents can be a potential anticancer strategy. For More Articles: Biomedical Research Articles : https://biomedres.us/

Focus on the Melatonin Metabolite N 1-Acetyl-5-methoxykynuramine (AMK) | The melatonin metabolite N¹-acetyl-5-methoxykynuramine (AMK) is a bioactive compound that acts as a potent inhibitor of cyclooxygenases, of neuronal NO synthase and myeloperoxidase, as a downregulator of cycloxygenase-2 and inducible NO synthase. Additionally, AMK is a potent scavenger of hydroxyl, peroxyl and carbonate radicals. It eliminates singlet oxygen more efficiently than histidine and related compounds. As a scavenger of all NO redox congeners, it forms a stable compound, 3-acetamidomethyl-6-methoxycinnolinone, that does not re-donate NO. Carbamoylating metabolites convert AMK into N-[2-(6-methoxyquinazolin-4-yl)-ethyl]-acetamide, another stable product. Upon oxidation, AMK forms an adduct-generating intermediate, which can attach to aromates, among them tyrosine and tryptophan. Protein AMKylation at tyrosines may cause inhibition of enzymes. With regard to receptor tyrosine kinases, this possibility may explain the observed growth inhibition in keratinocytes. For More Articles: Journal of Biomedical Research and Review : https://biomedres.us/