Persistent Eosinophilia is a Challenging Problem | HE is defined as >1.5 x 10⁹/L eosinophils in the blood on 2 examinations (interval >1 mo) and/or tissue HE defined by: eosinophils percentage in BM section exceeding 20% of all nucleated cells; and/or extensive eosinophilic tissue infiltration by pathologist opinion; and/or presence of marked deposition of eosinophil granule proteins (in the absence or presence of major tissue eosinophils infiltration). Eosinophilia is defined as an AEC >500/μL [1]. The severity of eosinophilia has been arbitrarily divided into mild (AEC: 500- 1,500/mm³), moderate (AEC: 1,500-5,000/mm³), and severe (AEC: >5,000/mm³) [2]. HE is defined as >1.5 x 10⁹/L eosinophils in the blood on 2 examinations (interval >1 mo) and/or tissue HE. Subtypes of HE are hereditary (familial); primary (clonal/ neoplastic) HE, secondary (reactive) HE; hypereosinophilic syndrome (HES) and HE of undetermined significance (HE_US) [3]. HE_US is a novel term in lieu of idiopathic hypereosinophilia [4]. Most eosinophilias are reactive. For More Articles: Journal of Biomedical Research and Reviews : https://biomedres.us/

What Is Happening to Medicine | What is happening to medicine? Are the dictums of Standard of Care outweighing the needs of those who are to be served? I think so. Take, for instance, the screening recommendations for prostate cancer. The USPSTF concluded several years ago, 2012 I believe, that screening for men younger than 75 “offered no benefit” to that age group. Insufficient evidence was their language. And if someone is over 75, then they recommend totally against screening. I have read the background to these recommendations. There have been extensive studies, those with PSA, those without PSA who get DRE (digital rectal exams). It is remarkable, really, that this has been the position for over half a decade by the preventative task force. But it is a challenge when in your training the 70’s and 80’s, through medical school, internship and residency, palpating the prostate and later the blood analyses (there are multiple ones now) was an integral part of examining men. For More Articles: Biomedical Research Articles : https://biomedres.us/

Inhibitors to Von Willebrand Factor in Type 3 Von Willebrand Disease (VWD) | Type 3 VWD is the least common and most severe among the three types of VWD. The incidence was estimated at 5-3/million and the severity is thought to be similar to mild or moderate hemophilia A. A recent report from the UK showed that failing to perform all required assays for the diagnosis of VWD Type 3, may occasionally result in giving a wrong diagnosis such as mild or moderate hemophilia A, a practice occasionally used by some hemostasis laboratories.[1] Type 3 VWD is usually associated with a clinical course that combines the mucous membranes bleeding features seen in patients with VWD as well as the deep muscle and joint bleeding encountered in patients with mild to moderate hemophilia. The lack of VWF, which usually protects and delays the degradation of FVIII result in very low level of FVIII activity, which contributes to the bleeding severity. The treatment of this condition is somewhat similar to that of patients with hemophilia which consists of infusions to replace the missing factors as on demand regimen using plasma derived (PD) products which contains both FVIII and VWF. Furthermore, many of the patients are currently on some form of prophylaxis to eliminate or decrease the frequency of bleeding episodes. For More Articles: Journal of Biomedical Research and Reviews : https://biomedres.us/

Recurrent Intraoral Herpes (RIH) Infection – A Case Report | Recurrent intraoral herpes (RIH) appears to be an infrequent problem. The lesions of RIH are characteristic and can usually be distinguished from others. The lesions of intra oral herpes may persist and be very serious in patients with a compromised immune system. Here we present a case of recurrent intraoral herpes infection in a young female which is uncommon. The herpes comes from greek word meaning to creep or crawl [1]. The human herpes virus family is officially known as Herpetoviridiae. Humans are only natural reservoir for these viruses, which are endemic worldwide & share many features. Best known member is Herpes simplex virus which exists in two types i.e. HSV -1 & HSV-2 [2]. Oral infection with herpes virus occurs in three clinical forms. The most common type consists of recurrent small blisters on the lips commonly referred to as fever blisters or secondary herpes labialis. The second type is a generalized oral infection called primary herpetic stomatitis. The third and least common form of recurrent oral herpes infection consists of small ulcers usually localized on palatal mucosa [2]. Recurrent intraoral herpes appears to be an infrequent problem. The lesions of RIH are characteristic and can usually be distinguished from others. The lesions of intra oral herpes may persist and be very serious in patients with a compromised immune system. While the virus may regress, it does not disappear. For More Articles: Scientific Research Articles on Biomedical : https://biomedres.us/

Does Single Locked Plating Provide A standard treatment Modality for Bicondylar tibial Plateau Fractures? A prospective study | Bicondylar tibial plateau fractures present a therapeutic challenge to the orthopaedic trauma surgeon, both in terms of the osseous injury as well as the concomitant soft-tissue insult. Double Plating with single incision or dual incisions provides more insult to the compromised soft tissue. However, single locking plate combines the technical advantages of an angular stable plate with those of the modern biological plating technique. The Study was held at Razi Orthopedic hospital in Kuwait. Between May 2012 and November 2013, 20 patients with a mean age of 37.65 years (Range from 24-57 years) with Bicondylar tibial plateau fractures with or without metaphyseal extension. Patients were diagnosed clinically, checked with standard X-rays; CT was done for all cases. Patients were treated by single lateral anatomically contoured locked plate through LISS or Polyaxial locking plate systems with or without additional screws from medial side. Radiological evaluation and functional assessment was done according to the Rasmussen Knee score. Patients were followed-up for an average of 12 months. For More Articles: Biomedical Journal Articles : https://biomedres.us/

Assessing the Quality of Perineal Auscultation for A Noninvasive Diagnosis of Urinary Bladder Outlet Obstruction | The current standard method for diagnosing bladder outlet obstruction in patients with Lower Urinary Tract Symptoms (LUTS) is a pressure-flow study. Electronic perineal auscultation, i.e. recording sound with a contact microphone behind the scrotum during voiding, might be an easy-to-use non-invasive alternative. Of major importance for the clinical applicability of perineal auscultation is the quality of the sound recording. In a clinical population of 74 male LUTS patients we studied two measures for assessing the quality of electronic perineal auscultation: a Normalized Correlation Coefficient (NCC) and Signal-To-Noise Ratio (SNR). We compared these measures with the visual assessment of the electronic auscultatory signal by three experienced observers. The agreement between the experienced observers was expressed using the Weighted Kappa statistic. Both quality measures were compared to the combined visual assessments using the Kruskal Wallis test and the usefulness was evaluated using ROC-analysis. For More Articles: Biomedical Open Access Journals : https://biomedres.us/

Plasma Lipid Profile and Uric Acid in High Fat Fed Female Rats Treated with Oral Contraceptive | A high fat diet is widely known in scientific consensus to be associated with abnormal lipid and uric acid metabolisms. The dose-related influence of Combined Oral Contraceptive (COC) in both human and animal models on blood lipid parameters is still controversial. Therefore the aim of the study is to investigate the effect of high fat diet (HFD) and two different doses of a COC on plasma lipid profile and uric acid in female wistar rats. Rats were divided into vehicle treated, high dose COC (HCOC, receiving 7.5μg Levonegestrel/1.5μg of estradiol), low dose COC, (LCOC receiving 1.5μg Levonegestrel/0.3μg of estradiol), High Fat (HF receiving 20%w/w of vegetable oil (turkey brand) supplemented feed), HF+HCOC (receiving both 7.5μg Levonegestrel/1.5μg estradiol and HFD) and HF+LCOC (receiving 1.5μg Levonegestrel/0.3μg of estradiol and HFD). Rats were given distilled water, HCOC, LCOC, HFD, HCOC+HF and LCOC+HF for 8 weeks. When compared with vehicle group, HCOC treatment led to a significant increase (P<0.05) in total cholesterol (TC). LCOC treatment also caused a significant rise (P<0.05) in total cholesterol, triglyceride and uric acid. Rats fed HFD showed a significantly higher (P<0.05) total cholesterol and Total/HDL-C ratio. HCOC+HF administration led to a significant elevation (P<0.05) of total cholesterol and Low density lipoprotein (LDL-C). LCOC+HF administration produced a significant increase in total cholesterol, LDL-C, Triglyceride/HDL-C ratio, Total/HDL-C ratio, LDL-C/HDL-C ratio and uric acid. In conclusion, combined oral contraceptive and high fat diet administrations resulted in an elevated total cholesterol and uric acid. The effect on Triglyceride/HDL-C, Total/HDL-C, LDL-C/HDL-C and uric acid was dependent on dose of the contraceptive, the effect on TC and LDL was not dose- dependent. Administrations of low dose of combined oral contraceptive and high fat diet may produce a greater cardiovascular risk than administration of high dose of combined oral contraceptive and high fat diet. For More Articles: Journal of Scientific and Technical Research : https://biomedres.us/

Ghost Cell Odontogenic Carcinoma-a review of the literature | Ghost Cell Odontogenic Carcinoma is an extremely rare odontogenic tumor with unclear etiology. Although known by many names, the basic histologic identifying feature includes the identification of the ghost cells and the malignant changes associated with the cells. These tumors show a spectrum of growth from a slow-growing locally invasive tumor to a highly aggressive, rapidly growing, infiltrative tumor. Therefore, it is prudent to perform a wide local excision with histologically clear margins. Is seen associated with squamous cell carcinoma, radiotherapy also should be included in the treatment plan. Long term follow-up is highly recommended. For More Articles: Biomedical Science Articles : https://biomedres.us/

Recent Advances in Metal Matrix Composites (MMCs): A Review | Metal matrix composites (MMCs) possess excellent physical and mechanical properties. The filler reinforcement into the metallic matrix improves the stiffness, specific strength, wear, creep and fatigue properties compared to the conventional engineering materials. The present work is a study of the effect of reinforcement of different types of fillers in metal matrix and their merits and demerits. Effect of different dispersion on the mechanical properties like tensile strength, strain, hardness, wear and fatigue of MMCs and its different applications are also highlighted in the paper. For More Articles: Biomedical Science Articles : https://biomedres.us/

Therapeutic Approach to Diabetes Mellitus Type 2 in People with Progressive Weight Gain: A Unique Case Study (Ucs) | Diabetes Mellitus (DM) is an important public health problem of our time [1]. According to European Health Survey in Spain, diabetes is 6.8% of the diagnosed chronic disease in people over the age of 15 in 2014 [2]. There are studies that claim that most chronic diseases, such as diabetes mellitus, are related to unhealthy lifestyles [3]. These lifestyles produce obesity in the people, associated causative factor of type 2 DM which in turn relates to an increased cardiovascular risk [3-4]. Diabetes Mellitus type 2 is a chronic and complex disease, which required continuous care. For that reason diabetes brings about 75.000 million euros of health expenditure in Europe [5], which means high levels of sanitary and economics costs. For More Articles: Biomedical Research Articles : https://biomedres.us/